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Tiemann-Boege Awarded Pilgerstorferpreis

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[2016/07/07] Assoc. Prof. Dr. Irene Tiemann-Boege was awarded the Pilgerstorferpreis from the Medical Society of Upper Austria.

Heißl awarded ÖAW Doc Fellowship

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[2016/03/04] Angelika Heißl's 3-year DOC fellowship granted by the Austrian Acadamy of Sciences (ÖAW) started on the 1 January 2016. The title is: "Meiotic recombination as a potential driver of microsatellite evolution". The Awards Ceremony (Stipendienverleihung) took place on 4 March 2016 in Vienna. ...  more of Heißl awarded ÖAW Doc Fellowship (Titel)

Tiemann-Boege: Winner of the OOE Forscherinnen Award 2015, Category “Gesundheit”

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Preis vom Land OÖ in der Kategorie für interdisziplinäre Forschung

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Assistant Professor Dr. Irene Tiemann-Boege and team won the 2015 Regional Award from the State of Upper Austria for Outstanding Research and Collaborative Effort. They were awarded winner in the category of Arts and Science.


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Publications

Journal Publications

New evidence for positive selection helps explain the paternal age effect observed in achondroplasia.
Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I.
Hum Mol Genet. 2013 Jun 14. (Epub ahead of print)

Massively Parallel Haplotyping on Microscopic Beads for the High-Throughput Phase Analysis of Single Molecules
Boulanger J, Muresan L, Tiemann-Boege I. 2012
PLoS One 7(4): e36064

In this work, a multiplex approach that allows the amplification of three loci within a 5 kilobase region of millions of single molecules in parallel was described. The method is based on similar principles to next-generation sequencing regarding library preparation, bead-amplification and emulsion PCR which provides an important foundation for sequencing recombinants with next generation sequencing approaches.

Evaluating the evidence for transmission distortion in human pedigrees
Evaluating the evidence for transmission distortion in human pedigrees. 2012
Genetics191(1): 215-32

Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel
Tiemann-Boege I, Curtis C, Shinde DN, Goodman D, Tavaré S, Arnheim N. 2009
Analytical Chemistry 81(14): 5770-6
[PDF]

This paper is about an ultimate high-throughput single molecule PCR method developed during my post-doctoral stay at the University of Southern California and the Johannes Kepler University. With this technology millions of single DNA molecules can be amplified in parallel on microscopic beads. It has been a turning point for my previously used technical approaches and has opened several other venues of research.

Mammalian hotspots of recombination
Arnheim N., Calabrese P., Tiemann-Boege I. 2007
Annu Rev Genet 41:369-99
[PDF]

Combining sperm typing and LD analyses reveals differences in selective pressures or recombination rates across human populations
Clark VJ, Ptak SE, Tiemann-Boege I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. 2007
Genetics 175(2):795-804.
[PDF]

Advancing age has differential effects of DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm
Wyrobyk AJ, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs EW, Glaser RL, Pearson FS, Evenson D. 2006
PNAS 103:9601-9606
[PDF]

High resolution recombination patterns in a region of human chromosome 21 measured by sperm typing
Tiemann-Boege I, Calabrese P, Cochran DM, Sokol RZ, Arnheim N. 2006
PLoS Genetics 2(5):e70.
[PDF]

In this work, we studied recombination hotspots and carried out a systematic survey of crossover rates using sperm typing during my post-doctoral stay at the University of Southern California. I developed a very efficient way of counting crossovers using real-time PCR that allowed me to count recombinants in millions of meioses. This work presented an important comparison of population genetics and sperm typing approaches and provided evidence about the possible co-regulation of hotspots of recombination. During that research, I stumbled across the intriguing properties of recombination hotspots.

The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect
Tiemann-Boege, I., Navidi, W., Grewal, R., Cohn, D., Eskenazi, B., Wyrobek, A. J., and Arnheim, N. 2002
PNAS 99: 14952-14957
[PDF]

This work on the paternal age effect was the first to accurately quantify new mutations in human sperm DNA, in the exciting and unconventional work on achondroplasia. It required the development of a very sensitive method that detected a single nucleotide change in a large pool of wild type genomes. It addressed the long discussed topic whether older men have a higher risk of transmitting new mutations. This study was the first to experimentally measure the mutational load on male germcells and pointed to the novel observation of selection at the level of germcells.

Rapidly evolving repetitive DNA in a karyotypically megaevolved genome: factors that affect chromosomal evolution
Bradley, R. D. , Martinez, R., Maltbie, M., Tiemann-Boege, I., Wichman H. A., Baker, R. J. 2003
Occasional Papers of the Museum of Texas Tech University, Number 223.

Molecular phylogenetics of the Peromyscus boylii species group
Tiemann-Boege, I., Kilpatrick, C. W., Schmidly, D. J. and Bradley, R. D. 2000
Molecular Phylogenetics and Evolution, 16:366-378.
[PDF]

Rapidly evolving repetitive DNA in a karyotypically megaevolved genome: factors that affect chromosomal evolution
Bradley, R. D. , Martinez, R., Maltbie, M., Tiemann-Boege, I., Wichman H. A., Baker, R. J. 2003
Occasional Papers of the Museum of Texas Tech University, Number 223.

Taxonomic status of Peromyscus boylii sacarensis: inferences from DNA sequences of the mitochondrial cytochrome b gene
Bradley, R. D., Tiemann-Boege, I., Kilpatrick, C. W. and Schmidly, D. J. 2000
Journal of Mammalogy, 81:875-884.
[Abstract]

Checklist of mammals from twelve habitat types at Fort Bliss Military Base
Clary, Melinda L., Bell, Darin M., Edwards, Cody W., Jolley, Ted W., Knyazhnitskiy, Oleksiy, Lewis-Oritt, Nicole, Mantooth, Stacy J., Peppers, Lottlie L., Tiemann-Boege, Irene, Yancey, II, Frank D., Howell, Donna J., Locke, Brian A., Baker, Robert J., and Bradley, Robert D. 1999; 1997-1998
Occasional Papers of the Museum of Texas Tech University, Number 192.

Comments on some small mammals from the Big Bend and Trans-Pecos regions of Texas
Bradley, Robert D. , Carroll, Darin S., Clary, Melinda L., Edwards, Cody W., Tiemann-Boege, Irene, Hamilton, Meredith J., Van Den Busche, Ronald A. and Jones, Clyde. 1999
Occasional Papers of the Museum of Texas Tech University, Number 193.

Published Conference Abstracts

High-throughput analysis of methylation patterns to track cell divisions
Tiemann-Boege I, Curtis C, Shibata D, Tavare S. 2008
Cellular Oncology, 30: 229-229.
Conference Information: 2nd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD)
MAY 04-07, 2008 Madrid, SPAIN.