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Tuning membrane protein mobility by confinement into nanodomains

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[2016/11/15] In cooperation with Prof. Peter Pohl (Institute of Biophysics, JKU), lead CBL researchers DI Andreas Karner and Dr. Johannes Preiner have developed a platform to study membrane proteins. ...  more of Tuning membrane protein mobility by confinement into nanodomains (Titel)

Linz Winter Workshop 2017

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3 to 6 February 2017 ...  more of Linz Winter Workshop 2017 (Titel)

Tiemann-Boege Awarded Pilgerstorferpreis

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[2016/07/07] Assoc. Prof. Dr. Irene Tiemann-Boege was awarded the Pilgerstorferpreis from the Medical Society of Upper Austria.

Heißl awarded ÖAW Doc Scholarship

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[2016/03/04] Angelika Heißl's 3-year DOC fellowship granted by the Austrian Acadamy of Sciences (ÖAW) started on the 1 January 2016. The title is: "Meiotic recombination as a potential driver of microsatellite evolution". ...  more of Heißl awarded ÖAW Doc Scholarship (Titel)

Cholesterol in the fight against allergies

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[2016/02/15] Cholesterol in the fight against allergies ...  more of Cholesterol in the fight against allergies (Titel)

Biophysics Researchers Discover New Immune Protein Structure

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[2016/02/05] Scientists at the JKU Institute for Biophysics (a working group under a. Univ. Prof. Christoph Romanin) have deciphered a key function in the “Orai1” immune protein. ...  more of Biophysics Researchers Discover New Immune Protein Structure (Titel)

Nanopharmacological force sensing to reveal allosteric coupling in transporter binding sites

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[2016/01/26] Novel tools for direct measurement of the interaction forces between the serotonin transporter and the S- and R-enantiomers of citalopram on the single molecule level allows for the demonstration of two distinct populations of characteristic binding strengths which provide physical evidence for the existence of two binding sites that are allosterically coupled and exert reciprocal modulation. ...  more of Nanopharmacological force sensing to reveal allosteric coupling in transporter binding sites (Titel)


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Content

2012

Electrostatically Induced Recruitment of Membrane Peptides into Clusters Requires Ligand Binding at Both Interfaces.
Antonenko YN, Horner A, Pohl P
PLoS ONE 7(12). Published: 21 December 2012.

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Increased imaging speed and force sensitivity for bio-applications with small cantilevers using a conventional AFM setup
Michael Leitner, Georg E. Fantner, Ernest J. Fantner, Katerina Ivanova, Tzvetan Ivanov, Ivo Rangelow, Andreas Ebner, Martina Rangl, Jilin Tang, Peter Hinterdorfer
Micron, Volume 43, Issue 12, December 2012, Pages 1399–1407.

Abstract  (Neues Fenster)

Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function
Muik M, Schindl R, Fahrner M, Romanin C.
Cell Mol Life Sci. 2012 Dec;69(24):4163-76.

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Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways
Andreas Scherfler, B. Doleschal, Michaela Lichtenegger, R. Oppenrieder, Isabella Derler, Irene Frischauf, T.N. Glasnov, C.O. Kappe, Christoph Romanin, K. Groschner.
British Journal of Pharmacology, Series 167, Vol. 8, Seite(n) 1712-1722, 12-2012.

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Single Molecular Recognition Force Spectroscopy Study of a Luteinizing Hormone-Releasing Hormone Analogue as a Carcinoma Target Drug
Jing Zhang, Guangmou Wu, Chunli Song, Yongjun Li, Haiyan Qiao, Ping Zhu, Peter Hinterdorfer, Bailin Zhang, and Jilin Tang
J. Phys. Chem. B, 2012, 116 (45), pp 13331–13337, October 24, 2012.

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Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane
Andreas Horner, Frank Goetz, Robert Tampe, Enno Klussmann, Peter Pohl
Journal of Biological Chemistry, 24 October 2012, in press.

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Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C.
J Biol Chem, 2012 Oct 12;287(42):35612-20.

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Design of Peptide-Membrane Interactions to Modulate Single-File Water Transport through Modified Gramicidin Channels.
Guillem Portella, Tanja Polupanow, Florian Zocher, Danila A. Boytsov, Peter Pohl, Ulf Diederichsen, Bert L. de Groot
Biophysical Journal, Volume 103, Issue 8, pp. 1698 - 1705. Published: 17 October 2012.

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Characterization of curli A production on living bacterial surfaces by scanning probe microscopy.
Oh YJ, Cui Y, Kim H, Li Y, Hinterdorfer P, Park S.
Biophys J. 2012 Oct 17;103(8):1666-71.

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Influenza virus binds its host cell using multiple dynamic interactions
Peter Hinterdorfer, Christian Sieben, Rong Zhu, Christian Rankl, Andreas Hermann, Christian Kappel, Anna Wozniak, Helmut Grubmüller.
PNAS, 8-2012

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Water at hydrophobic interfaces delays proton surface-to-bulk transfer and provides a pathway for lateral proton diffusion
Chao Zhang, Denis G. Knyazev, Yana A. Vereshaga, Emiliano Ippoliti, Trung Hai Nguyen, Paolo Carloni, Peter Pohl
Proceedings of the National Acadamy of Sciences, USA, Volume 109, Issue 25, pp. 9744-9749, Published: 19 June 2012.

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Analysis of the cell surface layer ultrastructure of the oral pathogen Tannerella forsythia.
Sekot, G., G. Posch, Y. J. Oh, S. Zayni, H. F. Mayer, D. Pum, P. Messner, P. Hinterdorfer, and C. Schaffer.
Archives of Microbiology, Volume194, Issue 6, pp. 525-539. Published: June 2012.

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Mechanochemical Study of Conformational Transitions in a Single Synthetic Peptide Chain
Sebastian Lecommandoux, Nicolas Willet, Peter Hinterdorfer, Anne-Sophie Duwez
NanoChem, June 2012.

Evaluating the evidence for transmission distortion in human pedigrees
Meyer WK, Arbeithuber B, Ober C, Ebner T, Tiemann-Boege I,Hudson RR, Przeworski M.
Genetics, Volume: 191, Issue: 1, pp: 215-32. Published: May 2012 (Epub 2012 Feb 29)

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Massively Parallel Haplotyping on Microscopic Beads for the High-Throughput Phase Analysis of Single Molecules
Boulanger J, Muresan L, Tiemann-Boege I.
PLoS ONE Volume: 7, Issue: 4, Article Number: e36064. Published: 30 April 2012.

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Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique
Lamprecht, C., N. Gierlinger, E. Heister, B. Unterauer, B. Plochberger, M. Brameshuber, P. Hinterdorfer, S. Hild, and A. Ebner
Journal of Physics-Condensed Matter, Volume 24, Issue 16, Article Number: 164206. Published: 25 April 2012.

Abstract  (Neues Fenster)

Painting with biomolecules at the nanoscale: biofunctionalization with tunable surface densities
Schlapak, R., J. Danzberger, T. Haselgrubler, P. Hinterdorfer, F. Schaffler, and S. Howorka
Nano Letters, Volume12, Issue 4, pp: 1983-1989, Published: April 2012.

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Uroplakins Do Not Restrict CO2 Transport through Urothelium
Zocher, F., M. L. Zeidel, A. Missner, T. T. Sun, G. Zhou, Y. Liao, M. von Bodungen, W. G. Hill, S. Meyers, P. Pohl, and J. C. Mathai
Journal of Biological Chemistry, Volume 287, Issue 14, pp. 11011-11017. Published: 30 March 2012.

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Structure, Regulation and Biophysics of I(CRAC), STIM/Orai1
Isabella Derler, Josef Madl, Gerhard Schütz, Christoph Romanin.
Advances in Experimental Medicine and Biology Volume 740, 2012, pp 383-410.

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Nanoscale DNA tetrahedra improve biomolecular recognition on patterned surfaces
Schlapak, R., J. Danzberger, D. Armitage, D. Morgan, A. Ebner, P. Hinterdorfer, P. Pollheimer, H. J. Gruber, F. Schaffler, and S. Howorka
Small, Volume: 8, Issue: 1, pp: 89-97. Published: 9 January 2012.

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Probing binding pocket of the serotonin transporter by single molecular force spectroscopy on living cells
Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou M-F, Zhu R, Freissmuth M, Sitte, HH, Hinterdorfer P.
Journal of Biological Chemistry, Volume 287, Issue 1, pp: 105-113. Published: 2 January 2012.

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Time-resolved chloroquine-induced relaxation of supercoiled plasmid DNA.
Mahut, M., M. Leitner, A. Ebner, M. Lammerhofer, P. Hinterdorfer, and W. Lindner
Analytical and Bioanalytical Chemistry, Volume 402, Issue 1, pp: 373-380. Published: January 2012.

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Topology-selective chromatography reveals plasmid supercoiling shifts during fermentation and allows rapid and efficient preparation of topoisomers
Mahut, M., E. Haller, P. Ghazidezfuli, M. Leitner, A. Ebner, P. Hinterdorfer, W. Lindner, and M. Lammerhofer
Angewandte Chemie-International Edition, Volume 51, Issue 1, pp: 267-270. Published: 2012.

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VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution
Revu Ann Alexander, Gerald W. Prager, Judit Mihaly-Bison, Pavel Uhrin, Stefan Sunzenauer, Bernd R. Binder, Gerhard J. Schütz, Michael Freissmuth and Johannes M. Breuss.
Cardiovasc Res (2012) 94 (1): 125-135. January 2012.

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