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Tuning membrane protein mobility by confinement into nanodomains

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[2016/11/15] In cooperation with Prof. Peter Pohl (Institute of Biophysics, JKU), lead CBL researchers DI Andreas Karner and Dr. Johannes Preiner have developed a platform to study membrane proteins. ...  more of Tuning membrane protein mobility by confinement into nanodomains (Titel)

Linz Winter Workshop 2017

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3 to 6 February 2017 ...  more of Linz Winter Workshop 2017 (Titel)

Tiemann-Boege Awarded Pilgerstorferpreis

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[2016/07/07] Assoc. Prof. Dr. Irene Tiemann-Boege was awarded the Pilgerstorferpreis from the Medical Society of Upper Austria.

Heißl awarded ÖAW Doc Scholarship

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[2016/03/04] Angelika Heißl's 3-year DOC fellowship granted by the Austrian Acadamy of Sciences (ÖAW) started on the 1 January 2016. The title is: "Meiotic recombination as a potential driver of microsatellite evolution". ...  more of Heißl awarded ÖAW Doc Scholarship (Titel)

Cholesterol in the fight against allergies

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[2016/02/15] Cholesterol in the fight against allergies ...  more of Cholesterol in the fight against allergies (Titel)

Biophysics Researchers Discover New Immune Protein Structure

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[2016/02/05] Scientists at the JKU Institute for Biophysics (a working group under a. Univ. Prof. Christoph Romanin) have deciphered a key function in the “Orai1” immune protein. ...  more of Biophysics Researchers Discover New Immune Protein Structure (Titel)

Nanopharmacological force sensing to reveal allosteric coupling in transporter binding sites

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[2016/01/26] Novel tools for direct measurement of the interaction forces between the serotonin transporter and the S- and R-enantiomers of citalopram on the single molecule level allows for the demonstration of two distinct populations of characteristic binding strengths which provide physical evidence for the existence of two binding sites that are allosterically coupled and exert reciprocal modulation. ...  more of Nanopharmacological force sensing to reveal allosteric coupling in transporter binding sites (Titel)


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2013

Local Partition Coefficients Govern Solute Permeability of Cholesterol-Containing Membranes
Florian Zocher, David van der Spoel, Peter Pohl and Jochen Hub
Biophysical Journal, 2013 Dec 17;105(12):2760-70.

Abstract  (Neues Fenster)

Single-Molecule Analysis of the Recognition Forces Underlying Nucleo-Cytoplasmic Transport
Martina Rangl, A. Ebner, J. Yamada, C. Rankl. R. Tampe, H.J. Gruber, M. Rexach and P. Hinterdorfer
Angewandte Chemie 2013, 125, 10546 –10549.

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The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.
Journal of Biological Chemistry, 13 August 2013, [Epub ahead of print]

Abstract  (Neues Fenster)

Long and short lipid molecules experience the same interleaflet drag in lipid bilayers
Andreas Horner, Akimov A. Sergey, and Peter Pohl
Physical Review Letters (PRL) 110, 268101, published 24 June 2013.

New evidence for positive selection helps explain the paternal age effect observed in achondroplasia.
Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I.
Hum Mol Genet. 2013 Jun 14. (Epub ahead of print)

Filter gate closure inhibits ion but not water transport through potassium channels
Torben Hoomann, Nadin Jahnke, Andreas Horner, Sandro Keller, and Peter Pohl.
Proc Natl Acad Sci U S A, 110, 10842-10847.

The bacterial translocon SecYEG opens upon ribosome binding
Denis G. Knyazev, Alexander Lents, Eberhard Krause, Nicole Ollinger, Christine Siligan, Daniel Papinski, Lukas Winter, Andreas Horner and Peter Pohl.
Journal of Biological Chemistry, 2013, 288:17941-17946.

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Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons
Kaya, Levent; Meissner, Barbara; Riedl, Maria Christine; Muik, Martin; Schwarzer, Christoph; Ferraguti, Francesco; Sarg, Bettina; Lindner, Herbert; Schweigreiter, Rudiger; Knaus, Hans-Gunther; Romanin, Christoph; Bandtlow, Christine E.
Biochimica et biophysica acta, volume:1833, issue: 6, pp: 1421-33. Published: June 2013

Abstract  (Neues Fenster)

Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC(4) Role in Neointimal Hyperplasia
Gonzalez-Cobos, Jose C.; Zhang, Xuexin; Zhang, Wei; Ruhle, Brian; Motiani, Rajender K.; Schindl, Rainer; Muik, Martin; Spinelli, Amy M.; Bisaillon, Jonathan M.; Shinde, Arti V.; Fahrner, Marc; Singer, Harold A.; Matrougui, Khalid; Barroso, Margarida; Romanin, Christoph; Trebak, Mohamed.
Circulation Research, volume:112, issue: 7, pp: 1013-U104. Published: 29 March 2013.

Abstract  (Neues Fenster)

Mapping the Nucleotide Binding Site of Uncoupling Protein 1 Using Atomic Force Microscopy
Zhu, Rong; Rupprecht, Anne; Ebner, Andreas; Haselgruebler, Thomas; Gruber, Hermann J.; Hinterdorfer, Peter; Pohl, Elena E.
Journal of the American Chemical Society, Volume:135, Issue: 9, pp.: 3640-3646. Published: 6 March 2013.

Abstract  (Neues Fenster)

Targeted Delivery of siRNA into Breast Cancer Cells via Phage Fusion Proteins
Deepa Bedi, James W. Gillespie, Vasily A. Petrenko, Jr., Andreas Ebner, Michael Leitner, Peter Hinterdorfer, and Valery A. Petrenko.
Molecular Pharmaceutics, 2013, 10 (2), pp 551–559. February 2013.

Abstract  (Neues Fenster)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
Derler, Isabella; Schindl, Rainer; Fritsch, Reinhard; Heftberger, P; Riedl, Maria Christine; Begg, M; House, David; Romanin, Christoph.
Cell Calcium, volume: 53, issue: 2, pp: 139-151. Published: February 2013.

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Atomic force microscopy functional imaging on vascular endothelial cells
Chtcheglova, Lilia A; Hinterdorfer, Peter.
Methods in Molecular Biology, volume: 931, pp.: 331-44, 2013.

Abstract  (Neues Fenster)

Functional AFM imaging of cellular membranes using functionalized tips
Lilia A. Chtcheglova, Peter Hinterdorfer.
Methods in Molecular Biology, volume 950, 2013, pp 359-371, 2013.

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