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Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells

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[2017/Nov/28] Dr. Irene Frischauf and Dr. Rainer Schindl made the cover of Science Signaling with their publication: Calcium regulates many vitally important functions in the body - if the calcium balance is defective, diseases like cancer develop... ...  more of Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells (Titel)

Noteworthy Publication in Angewandte Chemie

[2016/Nov/06] Publication in Angewandte Chemie: "Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins" ...  more of Noteworthy Publication in Angewandte Chemie (Titel)

Victoria Lunz - Genuinely Passionate about Research

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[February 2017] Photo credited to OÖ Nachrichten ...  more of Victoria Lunz - Genuinely Passionate about Research (Titel)

Tuning membrane protein mobility by confinement into nanodomains

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[2016/11/16] In cooperation with Prof. Peter Pohl (Institute of Biophysics, JKU), lead CBL researchers DI Andreas Karner and Dr. Johannes Preiner have developed a platform to study membrane proteins. ...  more of Tuning membrane protein mobility by confinement into nanodomains (Titel)

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Routes of Epithelial Water Flow: Aquaporins versus Cotransporters
Rustem Mollajew, F. Zocher, A. Horner, B. Wiesner, E. Klussmann, P. Pohl 2010.
Biophysical Journal, in press December 2010
Volume 99, Issue 11, 1 December 2010, Pages 3647-3656

Molecular recognition imaging using tuning fork-based transverse dynamic force microscopy.
Manuel Hofer, S. Adamsmaier, T. S. van Zanten, L. Chtcheglova, C. Manzo, M. Duman, B. Mayer, A. Ebner, M. Moertelmaier, G. Kada, M. F. Garcia-Parajo, P. Hinterdorfer, F. Kienberger. 2010.
Ultramicroscopy, Volume 110, Issue 6, May 2010, Pages 605-611

Improved localization of cellular membrane receptors using combined fluorescence microscopy and simultaneous topography and recognition imaging.
Memed Duman, M. Pfleger, R. Zhu, C. Rankl, L.A. Chtcheglova, I. Neundlinger, B.L. Bozna, B. Mayer, M. Salio, D. Shepherd, P. Polzella, M. Moertelmaier, G. Kada, A. Ebner, M. Dieudonne, G.J. Schütz, V. Cerundolo, F. Kienberger, P. Hinterdorfer. 2010.
Nanotechnology 21 (2010) 115504 (7pp)
[Full Text PDF]

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.
Johannes B. Huppa, M. Axmann, M. A. Mörtelmaier, B. F. Lillemeier, E. W. Newell, M. Brameshuber, L. O. Klein, G. J. Schütz, M. M. Davis
Nature 463, 963-967 (18 February 2010).

In-vivo detection of protein-protein interactions on micro-patterned surfaces
Julian Weghuber, S. Sunzenauer, M. Brameshuber, B. Plochberger, C. Hesch, G. J. Schütz
JoVE. 37., doi: 10.3791/1969
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Microarray analysis at single molecule resolution
Leila Muresan, J. Jacak, E. P. Klement, J. Hesse, G. J. Schütz
IEEE Trans Nanobioscience. 2010 Mar;9(1):51-8. Epub 2010 Jan 29

Direct observation and quantitative analysis of Lck exchange between plasma membrane and cytosol in living T cells
Lars Zimmermann, W. Paster, J. Weghuber, P. Eckerstorfer, H. Stockinger, G. J. Schütz
J. Biol. Chem. February 26, 2010 Vol. 285, No. 9 pp.6063-6070
[Full Text PDF]

Two-color Single Molecule Tracking Combined with Photobleaching for the Detection of Rare Molecular Interactions in Fluid Biomembranes
V. Ruprecht, M. Brameshuber, G. J. Schütz
Soft Matter, 2010, 6, 568–581

Atomic force microscopy studies of human rhinovirus: topology and molecular forces
Kienberger F, Zhu R, Rankl C, Gruber H, Blaas D, Hinterdorfer P 2010.
Methods Enzymol. 475:515-539.

Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns
Zhu R, Howorka S, Pröll J, Kienberger F, Preiner J, Hesse H, Ebner A, Pastushenko VP, Gruber HJ, Hinterdorfer P 2010.
Nat. Nanotech. 5:788-791.

Mapping short affinity tags on bacterial S-layer with antibody
Tang J, Ebner A, Kraxberger B, Badelt-Lichtblau H, Gruber HJ, Sleytr UB, Ilk N, Hinterdorfer P 2010.
ChemPhysChem 11:2323-2326.

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction
Graziani, A., M. Poteser, W. M. Heupel, H. Schleifer, M. Krenn, D. Drenckhahn, C. Romanin, W. Baumgartner, and K. Groschner. 2010.
J Biol Chem 285:4213-4223.

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.
Madl, J., J. Weghuber, R. Fritsch, I. Derler, M. Fahrner, I. Frischauf, B. Lackner, C. Romanin, and G. J. Schutz. 2010.
The Journal of biological chemistry 285:41135-41142.

Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.
Sponder, G., S. Svidova, R. Schindl, S. Wieser, R. J. Schweyen, C. Romanin, E. M. Froschauer, and J. Weghuber. 2010.
Febs J 277:3514-3525.

Detection of corneodesmosin on the surface of stratum corneum using atomic force microscopy.
Rankl, C., Zhu, R., Luengo, G. S. , Donovan, M. , Baghdadli, N., Hinterdorfer, P. . 2010.
Experimental Dermatology 19:1014–1019.

Fishing on Living Cells with AFM: Novel Method to Study Topology and Dynamics of Cotransporter SGLT1 Protein.
Puntheeranurak, T., R. K. H. Kinne, and P. Hinterdorfer. 2010.
Biophysical Journal 98:188a-189a.

Chemical tags mediate the orthogonal self-assembly of DNA duplexes into supramolecular structures.
Mitchell, N., A. Ebner, P. Hinterdorfer, R. Tampe, and S. Howorka. 2010.
Small 6:1732-1735.

Force-induced lysozyme--HyHEL5 antibody dissociation and its analysis by means of a cooperative binding model.
Katletz, S., C. Stroh, C. Rankl, U. M. Titulaer, and P. Hinterdorfer. 2010.
Biophys J 99:323-332.

Calibrated nanoscale capacitance measurements using a scanning microwave microscope.
Huber, H. P., M. Moertelmaier, T. M. Wallis, C. J. Chiang, M. Hochleitner, A. Imtiaz, Y. J. Oh, K. Schilcher, M. Dieudonne, J. Smoliner, P. Hinterdorfer, S. J. Rosner, H. Tanbakuchi, P. Kabos, and F. Kienberger. 2010.
Rev Sci Instrum 81:113701.

Segmental innervation in lumbosacral transitional vertebrae (LSTV): a comparative clinical and intraoperative EMG study.
Hinterdorfer, P., B. Parsaei, K. Stieglbauer, M. Sonnberger, J. Fischer, and G. Wurm. 2010.
J Neurol Neurosurg Psychiatry 81:734-741.

Higher dispersion efficacy of functionalized carbon nanotubes in chemical and biological environments.
Heister, E., C. Lamprecht, V. Neves, C. Tilmaciu, L. Datas, E. Flahaut, B. Soula, P. Hinterdorfer, H. M. Coley, S. R. Silva, and J. McFadden. 2010. ACS Nano 4:2615-2626.

Detecting protein aggregates on untreated human tissue samples by atomic force microscopy recognition imaging.
Creasey, R., S. Sharma, J. E. Craig, C. T. Gibson, A. Ebner, P. Hinterdorfer, and N. H. Voelcker. 2010.
Biophys J 99:1660-1667.

AFM functional imaging on vascular endothelial cells.
Chtcheglova, L. A., L. Wildling, J. Waschke, D. Drenckhahn, and P. Hinterdorfer. 2010.
J Mol Recognit 23:589-596.

Identification of immobile single molecules using polarization-modulated asynchronous TDI-mode scanning.
J. Jacak, C. Hesch, J. Hesse, G. J. Schütz.
Anal. Chem. 82 (2010) 4288-4292.

Temporal resolution of protein-protein interactions in the live-cell plasma membrane.
J. Weghuber, S. Sunzenauer, B. Plochberger, M. Brameshuber, T. Haselgrübler, G. J. Schütz.
Anal. Bioanal. Chem. 397 (2010) 3339-3347.

The antimicrobial and immunostimulatory peptide KLK induces an increase of the cytosolic Ca2+ concentration by mobilizing Ca2+ from intracellular stores.
J. Weghuber, A. M. Lipp, J. Stadlbauer, M. C. Aichinger, V. Ruprecht, A. Sonnleitner, G. J. Schütz, T. Henics.
Cell Biol. Int. 34 (2010) 1109-1112.

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.
B. Plochberger, T. Stockner, S. Chiantia, M. Brameshuber, J. Weghuber, A. Hermetter, P. Schwille, G. J. Schütz. Langmuir 26 (2010) 17322-17329.

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane
M. Brameshuber, J. Weghuber, V. Ruprecht, I. Gombos, I. Horváth, L. Vigh, P. Eckerstorfer, E. Kiss, H. Stockinger, G. J. Schütz.
J. Biol. Chem. 285 (2010) 41765-41771.