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Di 20.06.2017 17:15 GÖCH-OBERÖSTERREICH: Vortrag em. o.Univ.-Prof. Dr. Bernhard Kräutler
Institute of Organic Chemistry, University of Innsbruck

„B12 – Chasing a Moonlighting Vitamin with the Weapons of Synthesis”

„B12 – Chasing a Moonlighting Vitamin with the Weapons of Synthesis”
Abstract
Vitamin B12 (cyanocobalamin) is the original isolation form of the ‚extrinsic‘ ‚anti-perniciousanemia
factor‘. Strikingly, vitamin B12 is not directly physiologically active - it needs to be
tailored first by the enzyme CblC, and then further metabolized to the active B12-cofactors,
coenzyme B12 & methylcobalamin. What about cobalamins that resist tailoring by CblC ?
They cannot function ‘as B12’ - they can be ‘antivitamins B12’, and help elucidate the still
incompletely known physiological effects of the cobalamins, like vitamin B12. This lecture
will discuss the synthesis of novel cobalamins that are potential antivitamins B12, their
structural features and reactivity, as well as some of their basic biological effects


Link: http://www.jku.at/anorganik/

Ort:
Johannes Kepler Universität Linz
17.15 Uhr, HS 13 (TNF-Turm)

Kontakt:
Univ.-Prof. Dr. G. Knör
Tel. +43-732-2468-5100
anorganik(/\t)jku.at
http://www.jku.at/anorganik/

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