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Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells

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[2017/Nov/28] Dr. Irene Frischauf and Dr. Rainer Schindl made the cover of Science Signaling with their publication: Calcium regulates many vitally important functions in the body - if the calcium balance is defective, diseases like cancer develop... ...  more of Biophysics Researchers: Constant Calcium Uptake Causes Cancer in Cells (Titel)

Noteworthy Publication in Angewandte Chemie

[2016/Nov/06] Publication in Angewandte Chemie: "Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins" ...  more of Noteworthy Publication in Angewandte Chemie (Titel)

Victoria Lunz - Genuinely Passionate about Research

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[February 2017] Photo credited to OÖ Nachrichten ...  more of Victoria Lunz - Genuinely Passionate about Research (Titel)

Tuning membrane protein mobility by confinement into nanodomains

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[2016/11/16] In cooperation with Prof. Peter Pohl (Institute of Biophysics, JKU), lead CBL researchers DI Andreas Karner and Dr. Johannes Preiner have developed a platform to study membrane proteins. ...  more of Tuning membrane protein mobility by confinement into nanodomains (Titel)

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No facilitator required for membrane transport of hydrogen sulfide
John C. Mathai*, Andreas Missner*, Phillipp Kügler, Sapar M. Saparov, Mark L. Zeidel, John K Lee, Peter Pohl. 2009
PNAS, 29 September 2009, vol. 106, no.39, pp.16633-16638 (*contributed equally to the work)

Stable Non-Destructive Immobilization of Native Nuclear Membranes to Micro-Structured PDMS for Single-Molecule Force Spectroscopy
Martina Rangl, Reinat Nevo, Ivan Liashkovich, Victor Shahin, Ziv Reich, Andreas Ebner, and Peter Hinterdorfer. 2009
ChemPhysChem 2009 Jul 13;10(9-10):1553-8.

Topography and Recognition Imaging of Protein-Patterned Surfaces Generated by AFM Nanolithography
Rong Zhu, Andreas Ebner, Markus Kastner, Johannes Preiner, Stefan Howorka, and Peter Hinterdorfer. 2009
ChemPhysChem 2009 Jul 13;10(9-10):1478-81.

110 Years of the Meyer-Overton Rule: Predicting membrane permeability of gases and other small compounds
Andreas Missner and Peter Pohl. 2009
ChemPhysChem. 2009, 10, pp. 1405-1414

Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the SCID-related ORAI1 Mutant
Isabella Derler, Marc Fahrner, Oliviero Carugo, Martin Muik, Judith Bergsmann, Rainer Schindl, Irene Frischauf, Said Eshaghi and Christoph Romanin. 2009
J. Biol. Chem. 2009 June 5; 284(23): 15903–15915.
[Full Text PDF]

Coupled Diffusion of Peripherally bound Peptides along the Outer and Inner Membrance Leaflets
Andreas Horner, Yuri N. Antenenko and Peter Pohl. 2009
Biophysical Journal (2009), Vol. 96, April 2009, pp. 2689-2695.
[Abstract] [PDF]

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels
Martin Muik, Mark Fahrner, Isabella Derler, Rainer Schindl, Judith Bergsmann, Irene Frischauf, Klaus Groschner, and Christoph Romanin. 2009
J. Biol. Chem. (2009), Vol. 284, No. 13, pp. 8421-8426, March 27, 2009.
[Abstract] [PDF]

A mechanistic view of domains mediating STIM1-Orai coupling
Mark Fahrner, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C (2009) .
Immunol Rev 2009 Sep;231(1):99-112.

Recent progress on STIM1 domains controlling Orai activation.
Rainer Schindl, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C. 2009.
Cell Calcium 2009 Oct;46(4):227-32. Epub 2009 Sep 4.

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel
Rainer Schindl, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C.2009.
PNAS 2009 Nov 17;106(46):19623-8. Epub 2009 Nov 3.

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: Evidence for a regulatory TRPC4-{beta}-catenin interaction
Graziani A, Poteser M, Heupel W.-M, Schleifer M, Krenn M, Drenckhahn D, Romanin C, Baumgartner W, Groschner K .2009.
J. Biol. Chem. 2010 Feb 5;285(6):4213-23. Epub 2009 Dec 8.

AFM Imaging of functionalized double-walled carbon nanotubes.
Constanze Lamprecht, J. Danzberger, P. Lukanov, C.M. Tilmaciu, A.M. Galibert, B. Soula, E. Flahaut, H.J. Gruber, P. Hinterdorfer, A. Ebner, F. Kienberger. 2009.
Ultramicroscopy. Volume 109, Issue 8, July 2009, Pages 899-906.

AFM imaging of functionalized carbon nanotubes on biological membranes.
Constanze Lamprecht, I. Liashkovich, V. Neves, J. Danzberger, E. Heister, M. Rangl, H.M. Coley, J. McFadden, E. Flahaut, H.J. Gruber, P. Hinterdorfer, F. Kienberger, A. Ebner. 2009.
Nanotechnology 20 (2009) 434001 (7pp)

Imaging and detection of single molecule recognition events on organic semiconductor surfaces.
Johannes Preiner, N.S. Losilla, A. Ebner, P. Annibale, F. Biscarini, R. Garcia, P. Hinterdorfer. 2009.
Nano Letters 2009, 9 (2), pp 571–575.

Simultaneous topography and recognition imaging: Physical aspects and their implications for optimal imaging conditions.
J.Preiner, A. Ebner, L. Chtcheglova, R. Zhu, P. Hinterdorfer. 2009 .
Nanotechnology 20 (2009) 215103 (9pp).

Second Harmonic Atomic Force Microscopy Imaging of Live and Fixed Mammalian Cells
Alexander Dulebo, J. Preiner, F. Kienberger, G. Kada, C. Rankl, L. Chtcheglova, C. Lamprecht, D. Kaftan, P. Hinterdorfer. 2009. . Ultramicroscopy, Volume 109, Issue 8, July 2009, Pages 1056-1060

C-terminal Loop 13 of Na+/Glucose Cotransporter 1 Contains Both Stereospecific and Non-stereospecific Sugar Interaction Sites.
Barbara Wimmer, Raja M., Hinterdorfer P., Gruber H.J., Kinne R.K.-H. 2009.
J. Biol. Chem. 2009 Jan 9;284(2):983-91. Epub 2008 Nov 13.

Receptor Arrays for the Selective and Efficient Capturing of Viral Particles.
Philipp D. Pollheimer , Kastner M., Ebner A., Blaas D., Hinterdorfer P., Gruber H.J., Howorka S. 2009.
Bioconjugate Chem., 2009, 20 (3), pp 466–475.

Detection of metal binding sites on functional S-layer nanoarrays using single molecule force spectroscopy.
Jilin Tang, Ebner A., Kraxberger B., Leitner M., Hykollari A., Kepplinger C., Grunwald C., Gruber H.J., Tampé R., Sleytr U.B. Ilk N., Hinterdorfer P. (2009).
  J. Struct. Biol. Volume 168, Issue 1, October 2009, Pages 217-222.

A DNA Nanostructure for the Functional Assembly of Chemical Groups with tunable Stoichiometry and Defined Nanoscale.
Mitchell N., R. Schlapak, M. Kastner, D. Armitage, W. Chrzanowski,
J. Riener, P. Hinterdorfer, A. Ebner and S. Howorka. 2009.
Angew. Chem. Int. Ed. 2009, 48, 525 –527.

Aldosterone Receptor Sites on Plasma Membrane of Human Vascular Endothelium detected by a Mechanical Nanosensor.
Linda Wildling, P. Hinterdorfer, K. Kusche-Vihrog, Y. Treffner and H. Oberleithner. 2009.
Pflugers Arch - Eur J Physiol (2009) 458:223–230.

Cell-to-cell variability in the diffusion constants of the plasma membrane proteins CD59 and CD147
Stefan Wieser, J. Weghuber, M. Sams, H. Stockinger, G. J. Schütz
Soft Matter, 2009, 5, 3287–3294.

Two-Stage focus hold system for rapid ultra-sensitive readout of large area biochips
Clemens Hesch, J. Hesse, J. Jacak, G. J. Schütz
J Microscopy 2009 June ; 234(3): 251–254.

Reply to "Uncoupling diffusion and binding in FRAP experiments"
Mario Brameshuber, M. Schwarzenbacher, M. Kaltenbrunner, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stockinger, G. J. Schütz
Nature Methods 6, 183 - 184 (2009).

Genetically encoded FRET-sensors for the conformation of the Src-family kinase Lck
Wolfgang Paster, C. Paar, P. Eckerstorfer, A. Jakober, K. Drbal, G. J. Schütz, A. Sonnleitner , H. Stockinger Lck
The Journal of Immunology, 2009, 182, 2160 -2167
[Full Text PDF]

Plasma membrane fluidity affects transient immobilization of oxidized phospholipids in endocytotic sites for subsequent uptake
Sebastian Rhode, R. Grurl, M. Brameshuber, A. Hermetter, G. J. Schütz
J Biol Chem 284 (2009) 2258-2265
[Full Text PDF]

User-friendly, biocompatible miniature flow cell for fragile high fundamental frequency quartz crystal resonators.
Brigitte P. Sagmeister, Graz, I., Schwödiauer, R.,* Bauer, S., and Gruber, H. J. 2009.
Biosensors and Bioelectronics, Volume 24, Issue 8, 15 April 2009, Pages 2643-2648.

Stretching polysaccharides on live cells using single molecule force spectroscopy.
Francius, G., Alsteens, D., Dupres, V., Vanderleyden, J., Gruber, H. J., and Dufrêne, Y. F. (2009)
Nature Protocols 4, 939-946 (2009)

Geometry of Virus-Receptor Interaction Revealed by Site-Specific Fluorescence Quenchers and FRET-Analysis.
Wruss J., Pollheimer, P. D., Meindl, I., Reichel, A., Schulze, K., Schöfberger, W., Piehler, J., Tampé, R., Blaas, D., and Gruber, H. J.* .2009.
J. Am. Chem. Soc., Volume 131, No. 15, 2009, pp. 5478–5482.

Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel
Tiemann-Boege I, Curtis C, Shinde DN, Goodman D, Tavaré S, Arnheim N. 2009
Analytical Chemistry 81(14): 5770-6