This presentation will outline the goals and methods of the DESTINY (Design Thinking for Cyber-Physical Production Systems, CPPS) project. As indicated in the title, the project amalgamates methods from two separate disciplines: design thinking, including its foundations in the scientific study of design, and cyber-physical production systems, the basis of the Fourth Industrial Revolution (Industry 4.0). DESTINY applies a rigorous scientific methodology to develop a framework and methods for CPPS design thinking, and to theoretically and empirically validate the results. The methods to be developed include the integration of agile techniques, stakeholder collaboration and rapid prototyping in the CPPS development process. They aim to address primary research needs identified in a recent Plattform Industrie 4.0 study.