Go to JKU Homepage
Institute of Pharmacology
What's that?

Institutes, schools, other departments, and programs create their own web content and menus.

To help you better navigate the site, see here where you are at the moment.



  1. Spix B., Butz E.S., Chen C.C., Plesch E., Wartenberg P., Scotto Rosato A., Arlt E., Briukhovetska D., Jeridi A., Wyatt A., Kissing S., Teupser D., Holdt L.M., Boehm U., García-Añoveros J., Saftig P., Schiller H.B., Kobold S., Boekhoff I., Zierler S., Wahl-Schott C., Gudermann G., Bracher F., Yildirim A.Ö., Biel M., Grimm C. Impaired MMP-12 clearance and emphysema-like phenotype in mucolipin 3 deficient mice. Nature Communications 2022, 13(1):318. doi: 10.1038/s41467-021-27860-x

  2. T. Shahin, D. Mayr, M.R. Shoeb, H.S. Kuehn, B. Hoeger, …, S.D. Rosenzweig, K. Boztug (2021) Identification of Germline Monoallelic Mutations in IKZF2 in Patients with Immune Dysregulation. Blood Advances, 2021006367.

  3. T. Shahin, H.S. Kuehn, M.R. Shoeb, Gawriyski L., Giuliani S., Repiscak P, B. Hoeger, Ö.Y. Petronczki, S. Köstel Bal, S. Zoghi, J. Dmytrus, D. Seruggia, I. Castanon, N. Rezaei, M. Varjosalo, F. Halbritter, S.D. Rosenzweig, K. Boztug (2021) Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity. Science Immunology 6, 65.

  4. Steiner, P.+, O., Buchner+, A., Andosch, A., Holzinger, U., Lütz-Meindl and G., Neuner. 2021. Winter survival of the unicellular green alga Micrasterias denticulata: insights from field monitoring and simulation experiments. Protoplasma. 259:1335. (+ Joint first authors)

  5. Michelini, S., F. Barbero, A. Prinelli, P. Steiner, R. Weiss, T. Verwanger, A. Andosch, U. Lütz-Meindl, V. F. Puntes, D. Drobne, A. Duschl, J. Horejs-Hoeck. 2021. Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structure. Nanoscale. 13:7648.

  6. Nadolni W., Immler R., Hoelting K., Fraticelli M., Ripphahn M., Rothmiller S., Matsushita M., Boekhoff I., Gudermann T., Sperandio M., Zierler S. TRPM7 Kinase is essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling. Frontiers in Immunology  2021 doi: 10.3389/fimmu.2020.606893

  7. E. Salzer, S. Zoghi, M.G. Kiss, F. Kage, C. Rashkova, S. Stahnke, M. Haimel, R. Platzer, M. Caldera, R.C. Ardy, B. Hoeger, J. Block, D. Medgyesi, C. Sin, S. Shahkarami, R. Kain, V. Ziaee, P. Hammerl, C. Bock, J. Menche, L. Dupre, J.B. Huppa, M. Sixt, A. Lomakin, K. Rottner, C.J. Binder, T.B. Stradal, N. Rezaei, K. Boztug (2020) The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology 5, eabc3979.

  8. M. Thian, B. Hoeger, A. Kamnev, F. Poyer, S. Köstel Bal, M. Caldera, R. Jimenez Heredia, J. Huemer, W.F. Pickl, M. Groß, S. Ehl, C.L. Lucas, J. Menche, C. Hutter, A. Attarbashi, L. Dupre, K. Boztug (2020) Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation. Haematologica 105, e488.

  9. Arlt E., Fraticelli M., Tsvilovskyy V., O’Neill T.J., Wennemuth G., Breit A., Wahl-Schott C., Biel M., Freichel M., Grimm C., Gudermann T., Klugbauer N., Boekhoff I, Zierler S. Targeting the two-pore channel TPC1 augments systemic anaphylaxis and mast cell activity. Proceedings of the National Academy of Sciences of the United States of America 2020 117:18068-18078. doi: 10.1073/pnas.1920122117

  10. Gerndt S., Chen C., Chao Y., Yuan Y., Burgstaller S., Scotto Rosato A., Krogsaeter E., Urban N., Jacob K., Nguyen O.N.P., Miller M.T., Keller M., Vollmar A.M., Gudermann T., Zierler S., Schredelseker J., Schaefer M., Biel M., Malli R., Wahl-Schott C., Bracher F., Patel S., Grimm C. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. eLife, 2020 doi: 10.7554/eLife.54712

  11. Steiner, P., O., Buchner, A., Andosch, G., Wanner, G., Neuner and U., Lütz-Meindl. 2020. Fusion of mitochondria to 3-D networks, autophagy and increased organelle contacts are important subcellular hallmarks during cold stress in plants. International Journal of Molecular Science. 21:8753.

  12. Steiner, P., S. Obwegeser, G. Wanner, O. Buchner, U. Lütz-Meindl and A. Holzinger. 2020. Cell wall reinforcements accompany chilling and freezing stress in the streptophyte green alga Klebsormidium crenulatum. Frontiers of Plant Science. 11:873.

  13. Buchner+, O. & P. Steiner+, A. Andosch, A. Holzinger, M. Stegner, G. Neuner and U. Lütz-Meindl. 2020. A new technical approach for preparing frozen biological samples for electron microscopy. Plant Methods. 48:16. (+ Joint first authors)

  14. N.K. Serwas*, B. Hoeger*, R.C. Ardy, S.V. Stulz, Z. Sui, …, D.M. Sansom, Y.T. Bryceson, A. Altman, K. Boztug (2019) Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature Communications 10, 3106. (*geteilte Erstautorenschaft)

  15. Voringer S., Schreyer L., Nadolni W., Woerther K., Mittermeier C., Ferioli S., Singer S., Holzer K., Zierler S., Chubanov V., Liebl B., Gudermann T., Muehlich S., Targeted inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity. Oncogene 2019 doi: 10.1038/s41388-019-1140-8,

  16. Steiner, P., M. Luckner, H. Kerschbaum, G. Wanner and U. Lütz-Meindl. 2018. Ionic stress induces fusion of mitochondria to 3-D networks: An electron tomography study. Journal of Structural Biology. 204:52-63.

  17. B. Hoeger, N.K. Serwas, K. Boztug (2018) Human NF-kB1 haploinsufficiency and Epstein-Barr virus-induced disease – Molecular mechanisms and consequences. Frontiers in Immunology 8, 1978. Review

  18. Romagnani A, Vettore V, Rezzonico-Jost T., Hampe S., Rottoli E., Nadolni W., Perotti M., Geiger S., Wennemuth G., Recordati C., Matsushita M., Proietti M., Chubanov V., Gudermann T., Grassi F., Zierler S. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nature Communications 2017 8:1917. doi: 10.1038/s41467-017-01960-z