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Institut für Biophysik Institut für Biophysik


 

Single-file transport of water through membrane channels

Abstract

Horner  A., Pohl P., Faraday Discussions, 2018 June 18, 10.1039/C8FD00122G

Positively charged residues at the channel mouth boost single-file water flow

Abstract

Horner A., Siligan C., Cornean  A., Pohl P., Faraday Discuss, 2018 April 2, 10.1039/C8FD00050F

Driving Forces of Translocation Through Bacterial Translocon SecYEG

Abstract

Knyazev D., Kuttner R., Zimmermann M., Sobakinskaya E., Pohl P., The Journal of membran biology,  2018 Jun 251(3):329-343. doi: 10.1007/s00232-017-0012-9. Epub 2018 Jan 12.

Label-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scales

Abstract

Tarun O., Hannesschlaeger C., Pohl P., Roke S., PNAS, April 2 2018. 201719347

Mechanism of Long-Chain Free Fatty Acid Protonation at the Membrane-Water Interface

Abstract

Pashkovskaya A., Vazdar M.,  Zimmermann, L., Jovanovic O., Pohl P., Pohl E., Biophysics Journal 2018 May, 8;114(9):2142-2151. doi: 10.1016/j.bpj.2018.04.011.

Interfacial water molecules at biological membranes: Structural features and role for lateral proton diffusion

Abstract

Nguyen T.,  Zhang C., Weichselbaum E., Knyazev D., Pohl P., Carloni P., PLOS ONE, 2018 February 23, 13 (2), e0193454.

 

Comment on “Enhanced water permeability and tunable ion selectivity in subnanometer carbon nanotube porins”

Abstract

Horner A., Pohl P., Science 2018 March, 30: Vol. 359, Issue 6383, eaap9173 DOI: 10.1126/science.aap9173

Quantification of Water Flux in Vesicular Systems

Abstract

Hannesschläger, C.; Barta, T.; Siligan, C.; Horner, A.,2018 June 4, Scientific Reports  8 (1), 8516.

Unitary Water Channel Permeability and Arrhenius Activation Energy are Intricately Linked

Abstract

Horner A., Pohl P., Biophys. J., 2018 February 2, 114:493A-494A

2017

Undulations Drive Domain Registration from the Two Membrane Leaflets

Abstract

Timur R., Peter P., Kuzmin, Peter Pohl und Sergey A. Akimov.
Biophysical Journal 2017. Volume 112, pp. 339-345. January 24 2017

Tuning membrane protein mobility by confinement into nanodomains.

Abstract

Karner, A., B. Nimmervoll, B. Plochberger, E. Klotzsch, A. Horner, D. G. Knyazev, R. Kuttner, K. Winkler, L. Winter, C. Siligan, N. Ollinger, P. Pohl, and J. Preiner. 2017. Nat. Nanotech. 12:260-266.

YidC and SecYEG form a heterotetrameric protein translocation channel

Abstract

Sachelaru, I., Winter, L., Knyazev, D.G., Vogt, A., Kuttner, R., Ollinger, N., Siligan, C., Pohl, P., and Koch, H.G. 2017. Sci. Reports. 7:101.

Origin of proton affinity to membrane/water interfaces

Weichselbaum, E., Österbauer, M., Knyazev, D. G., Batishchev, O. G., Akimov, S. A., Nguyen, T., Zhang, C., Knör, G., Agmon, N., Carloni, P., and Pohl, P. Sci. Reports. In press, DOI:10.1038/s41598-017-04675-9.

Driving Forces of Translocation Through Bacterial Translocon SecYEG

Abstract

Denis G. Knyazev, Roland Kuttner, Mirjam Zimmermann, Ekaterina Sobakinskaya, Peter Pohl

Caged Protons as Tools for Studying Transport of Protons along Lipid Bilayers
 

Abstract

Österbauer, M.Weichselbaum, E. Pohl, P. Knör, G., Biophysical Journal, 2017 January 3, Vol. 112, Seite(n) 277a

 

Stable Europium(III) Complexes with Short Linkers for Site‐Specific Labeling of Biomolecules
 

Abstract

Faschinger, F. Ertl, M. Zimmermann, M. Horner, A. Himmelsbach, M. Schöfberger, W. Knör, G. Gruber, J.H., ChemistryOpen, 2017 September 4, Vol. 6, Seite(n) 721-732, 2017

 

Study of adsorption of Influenza virus matrix protein M1 on lipid membranes by the technique of fluorescent probes
 

Abstract

Knyazev, D. Batishchev, O. Shilova, L.A. Fedorova, N.V. Shtykova, E.V., Biochemistry (Moscow), Supplement Series: Membrane and Cell Biology,2017 July , Volume 11,Issue 3, pp 225–230

New Thiol-Reactive Eu-Complex for Distance Measurements by LRET
 

2016

Tuning membrane protein mobility by confinement into nanodomains

Abstract

Karner A., Nimmervoll B., Plochberger B., Klotzsch E., Horner A., Knyazev D., Kuttner R., Winkler K., Winter L., Siligan C., Ollinger N., Pohl P., Preiner J. Nature Nanotechnology. 2016 Nov 14. doi: 10.1038/nnano.2016.236

Protons and Hydroxide Ions in Aqueous Systems

Abstract

Noam Agmon, Huib J. Bakker, R. Kramer Campen, Richard H. Henchman, Peter Pohl, Sylvie Roke, Martin Thämer, and Ali Hassanali
Chem. Rev. DOI: 10.1021/acs.chemrev.5b00736, 17 June 2016

 

Voltage-sensitive styryl dyes as singlet oxygen targets on the surface of bilayer lipid membrane

Abstract

V.S. Sokolov, A.N. Gavrilchik, A.O. Kulagina, I.N. Meshkova, P. Pohl, and Yu.G. Gorbunova
Journal of Photochemistry and Photobiology, Volume 161, August 2016, pp. 162-169

 

Water Determines the Structure and Dynamics of Proteins

Abstract

Marie-Claire Bellissent-Funel, Ali Hassanali, Martina Havenith, Richard Henchman, Peter Pohl, Fabio Sterpone, David van der Spoel, Yao Xu, and Angel E Garcia¶
Chem. Rev., 17 May 2016

 

The Sodium Glucose Cotransporter SGLT1 is an Extremely Efficient Facilitator of Passive Water Transport

Abstract

Liudmila Erokhova, Andreas Horner, Nicole Ollinger, Christine Siligan and Peter Pohl
J Biol Chem. 2016 April 29; 291 (18), pp. 9712-20

Comment on "Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains" Reply

Abstract

Timur R. Galimzyanov, Rodion J. Molotkovsky, Fredric S. Cohen, Peter Pohl and Sergey A. Akimov
(2016). Phys.Rev. 

Cholesterol modulates Orai1 channel function

Abstract

Isabella Derler, Isaac Jardin, Peter B. Stathopulos, Martin Muik, Marc Fahrner, Vasilina Zayats, Saurabh K. Pandey, Michael Poteser, Barbara Lackner, Marketa Absolonova, Rainer Schindl, Klaus Groschner, Rüdiger Ettrich, Mitsu Ikura and Christoph Romanin

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

Abstract

Dr. Rong Zhu, Dr. Doris Sinwel, Dr. Peter S. Hasenhuetl, Kusumika Saha, Dr. Vivek Kumar, Dr. Peng Zhang, Dr. Christian Rankl, Marion Holy, Dr. Sonja Sucic, Dr. Oliver Kudlacek, Andreas Karner, Dr. Walter Sandtner, Dr. Thomas Stockner, Prof. Dr. Hermann J. Gruber, Prof. Dr. Michael Freissmuth, Dr. Amy Hauck Newman, Prof. Dr. Harald H. Sitte andProf. Dr. Peter Hinterdorfer
Angewandte Chemie International Edition, Volume 55, Issue 5, pages 1719–1722, January 26, 2016.

Elastic deformations of bolalipid membranes

Abstract

Timur R. Galimzyanov, Peter I. Kuzmin, Peter Pohl and Sergey A. Akimov
Soft Matter, 12, 2357-2364. Published January 2016

Key Differences in Molecular Transport Mechanisms of Uncoupling Proteins
 

Abstract

Macher, G. Köhler, M. Rupprecht, A. Hinterdorfer, Pohl, E., Biophysical Journal, ,2016 February 16, Vol. 110, Nummer 3, Elsevier, 2-2016


Binding Mechanism of Purine Nucleotides to Mitochondrial Uncoupling Proteins Explored by Recognition Force Spectroscopy
 

Abstract

Köhler, M. Macher, G. Rupprecht, A. Zhu, R. Gruber, H. Pohl, E. Hinterdorfer, P., Biophysical Journal, 2016 February 16, Volume 110, Issue 3  

 

pH-Dependent Formation and Disintegration of the Influenza A Virus Protein Scaffold To Provide Tension for Membrane Fusion
 

Abstract

Batishchev, O. Shilova, L.A. Kachala, M.V. Tashkin, V.Y. Sokolov, V.S. Fedorova, N.V. Knyazev, D., Journal of virology, 2016 January 1, 90(1):575-85. doi: 10.1128/JVI.01539-15

Curli mediate bacterial adhesion to fibronectin via tensile multiple bonds
 

Abstract

Jin Oh, Y. Hubauer-Brenner, M. Gruber, H. Cui, Y. Traxler, L. Siligan, C. Park, S. Hinterdorfer, P., Scientific Reports, 2016 September 22, 6:33909. doi: 10.1038/srep33909

2015

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

Abstract

Irene Frischauf, Vasilina Zayats, Michael Deix, Anna Hochreiter, Isaac Jardin, Martin Muik, Barbara Lackner, Barbora Svobodová, Teresa Pammer, Monika Litviňuková, Amrutha Arumbakam Sridhar, Isabella Derler, Ivan Bogeski, Christoph Romanin, Rüdiger H. Ettrich and
Rainer Schindl, Sci. Signal. 22 Dec 2015: Vol. 8, Issue 408, pp. ra131

Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains

Abstract

Timur R. Galimzyanov, Rodion J. Molotkovsky, Marine E. Bozdaganyan, Fredric S. Cohen, Peter Pohl, and Sergey A. Akimov
Physical Review Letters 115, 088101. Published 18 August 2015

 

The mobility of single-file water molecules is governed by the number of H-bonds they may form with channel-lining residues

Abstract

Andreas Horner, Florian Zocher, Johannes Preiner, Nicole Ollinger, Chistine Siligan, Sergey A. Akimov and Peter Pohl
Sci. Adv. Vol. 1, no. 2, published March 2015.

Crossovers are associated with mutation and biased gene conversion at recombination hotspots

Abstract

Barbara Arbeithuber, Andrea J. Betancourt, Thomas Ebner and Irene Tiemann-Boege, PNAS, vol. 12, no. 7, pp: 2109-2114, published: 17 February 2015

Aquaporin 5 expression in mouse mammary gland cells is not driven by promoter methylation

Abstract

Barbara Arbeithuber, Roland Thuenauer, Yasmin Gravogl, Zsolt Balogi, Winfried Romer, Alois Sonnleitner and Irene Tiemann-Boege
BioMed research international, Volume:2015, Feb 2015

High-Speed AFM Images of Thermal Motion Provide Stiffness Map of Interfacial Membrane Protein Moieties

Abstract

Johannes Preiner, Andreas Horner, Andreas Karner, Nicole Ollinger, Christine Siligan, Peter Pohl, Peter Hinterdorfer.
Nano Letters, Volume: 15, Issue: 1, pp: 759-763, Published: January 2015.

 

2014

Switchavidin: Reversible Biotin-Avidin-Biotin Bridges with High Affinity and Specificity

Abstract

Barbara Taskinen, Dominik Zauner, Soili I. Lehtonen, Masi Koskinen, Chloe Thomson, Niklas Kahkonen, Sampo Kukkurainen, Juha A. E. Maatta, Teemu O. Ihalainen, Markku S. Kulomaa, Hermann J. Gruber, Vesa P.
Bioconjugate Chemistry, Volume: 25, Issue: 12, pp: 2233-2243, Published: December 2014

 

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

Abstract

Marc Fahrner, Martina Muik, Rainer Schindl, Carmen Butorac, Peter Stathopulos, Le Zheng, Isaac Jardin, Mitsuhiko Ikura, Christoph Romanin.
Journal of Biological Chemistry, Volume: 289, Issue: 48, Pages: 33231-33244 Published: 28 Nov 2014

TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

Abstract

Maylis Raphael, V'yacheslav Lehen'kyi, Matthieu Vandenberghe, Benjamin Beck, Sergiy Khalimonchyk, Abeele, Fabien Vanden, Leonardo Farsetti, Emmanuelle Germain, Alexandre Bokhobza, Adriana Mihalache, Pierre Gosset, Christoph Romanin, Philippe Clezardin, Roman Skryma, Natalia Prevarskaya.
PNAS, Volume: 111, Issue: 37, pp: E3870-E3879, Published: 16 September 2014

 

Ion Conductivity of the Bacterial Translocation Channel SecYEG Engaged in Translocation

Abstract

Denis G. Knyazev, Lukas Winter, Benedikt W. Bauer, Christine Siligan, and Peter Pohl
J. Biol. Chem., 29 August 2014, 289, pp. 24611-24616

 

Forces and Dynamics of Glucose and Inhibitor Binding to Sodium Glucose Co-transporter SGLT1 Studied by Single Molecule Force Spectroscopy

Abstract

Isabel Neundlinger, Theeraporn Puntheeranurak, Linda Wildling, Christian Rankl, Lai-Xi Wang, Hermann J. Gruber, Rolf K.H. Kinne, Peter Hinterdorfer.
Journal of Biological Chemistry, Volume: 289, Issue: 31, pp: 21673-21683, Published: 1 August 2014.

IgGs are made for walking on bacterial and viral surfaces

Abstract

Johannes Preiner, Noriyuki, Jilin L. Tang, Andreas Ebner, Mario Brameshuber, Dieter Blaas, Nicola Gelbmann, Hermann J. Gruber, Toshio Ando, Peter Hinterdorfer.
Nature Communications, Volume: 5, Article No.: 4394, Published: July 2014

 

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

Abstract

Xuexin Zhang, Wie Zhang,Jose C.Gonzalez-Cobos, Isaac Jardin, Christoph Romanin, Khalid Matrougui, Mohamed Trebak.
Journal of General Physiology, Volume: 143, Issue: 3, pp: 345-359, Published: March 2014

 

Investigating the binding behaviour of two avidin-based testosterone binders using molecular recognition force spectroscopy

Abstract

Martina Rangl, Michael Leitner, Tiina Riihimaki, Soili Lehtonen, Vesa P. Hytonen, Hermann J Gruber, Markku Kulomaa, Peter Hinterdorfer, Andreas Ebner.
Journal of Molecular Recognition, Volume: 27, Issue: 2 pp: 92-97, Published: February 2014

 

Kinetics of bioconjugate nanoparticle label binding in a sandwich-type immunoassay

Abstract

Tuomas Nareoja, Andreas Ebner, Hermann J. Gruber, Barbara Taskinen, Ferry Kienberger, Pekka E. Hanninen, Vesa P.Hytonen, Peter Hinterdorfer, Harri Harma.
Analytical and Bioanalytical Chemistry, Volume: 406, Issue: 2 pp: 493-503, Published: January 2014

 

Real-Time Monitoring of Membrane-Protein Reconstitution by Isothermal Titration Calorimetry

Abstract

Nadin Jahnke, Oxana O. Krylova, Torben Hoomann, Carolyn Vargas, Sebastian Fiedler, Peter Pohl, and Sandro Keller
Anal. Chem., 2014, 86 (1), pp 920–927. 7 January 2014.

 

Combined Single Molecule Recognition Imaging and Force Spectroscopy to Study the Interactions Between Uncoupling Proteins and Purine Nucleotides
 

Abstract

Köhler, M. Pürstinger, G. Zhu, Rong. Rupprecht, A. Gruber, H.J. Pohl, E. Hinterdorfer, P., Biophysical Journal, 2014 January, Volume 106, Issue 2,

High-speed AFM images of thermal motion provide stiffness map of interfacial membrane protein moieties

Abstract

Preiner, J. Horner, A. Karner, A. Öllinger, N. Siligan, C. Pohl, P. Hinterdorfer, P., Nano Letters , 2015, 15 (1), pp 759–763