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Institut für Biophysik Institut für Biophysik

SINGLE MOLECULE GENETICS

Members from left to right:
Irene Tiemann-Boege, Angelika Heißl, Theresa Schwarz, Yasmin Striedner, Nicole Zeppezauer, Maja Ivankovic, Sofia Moura, Renato Salazar, Ingrid Hartl, Covadonga Vara, Marion Müller

Irene Tiemann-Boege

Head of Single Molecule Genetics
 

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Curriculum Vitae

Education

2015

Venia docendi (Habilitation) in Molecular Genetics, Johannes Kepler University, Linz

2003

Ph.D. in Molecular Biology, University of Southern California, Los Angeles, USA. Advisor: Norman Arnheim

1999

M.Sc. in Zoology, Texas Tech University, Lubbock, USA. Advisor: Robert D. Bradley

1997

B.Sc. and M.Sc. in Biology--summa cum laude, Universidad de las Américas, México. Advisor: Dr. Javier Garcés-Eisele.

1994-1995

Exchange student at McGill University, Montreal, Canada

 

Professions

2015-

Associate Professor and Senior Group Leader of Single Molecule Genetics, Institute of Biophysics, Johannes Kepler University, Austria

2010-2015

Assistant Professor and Group Leader of Single Molecule Genetics, Institute of Biophysics, Johannes Kepler University, Austria

2009-2010

Assistant Professor and Group Leader of Single Molecule Genetics, Institute of Biophysics, Johannes Kepler University, Austria

2007-2008

Senior Research Associate, Department of Oncology, University of Cambridge, UK

2003-2007

Postdoctoral Research Associate, Department of Molecular and Computational Biology, University of Southern California, USA

1999-2003

Research Assistant, Department of Molecular and Computational Biology, University of Southern California, USA

1997-1999

Research Assistant, Department of Zoology, Texas Tech University, USA

 

Funding

2018-2022

DK NanoCell, University of Linz; Co-PI

2019-2022

FWF the Austrian Science Fund (P30867-B26). Age related mutagenesis of driver genes in the male germline. Principal Investigator.

2017-2019

Linz Institute of Technology (LIT). Seed research grant. Discovery of New mutations using ultra-sensitive sequencing. Principal Investigator.

2014-2018

FWF the Austrian Science Fund (P27698). Binding properties of PRDM9. Principal Investigator.

2013-2017

FWF the Austrian Science Fund (P25525). Higher mutations in older men. Principal Investigator.

2011-2015

FWF the Austrian Science Fund (P23811-B12). Mutagenic recombination. Principal Investigator

2006-2007

Center of Excellence in Genomic Sciences (NHGRI), Pilot Grants by the University of Southern California (ITI0701821).

 

Fellowships

2009-2010

Lise Meitner fellowship awarded by the Austrian Science Funds

1999-2003

Doctoral Grant. Consejo Nacional de Ciencia y Tecnologia (CONACYT), the Mexican Ministry of Science and Technology.

1999

Fellowship from the Association for the Advancement of Women in Science

1998-1999

Chancellor Fellowship of the Texas Tech University, Texas.

 

Awards and Achievements

2016

Pilgerstorferpreis awarded by the Upper Austrian medical society for outstanding scientific achievements

2015

Upper Austrian researcher of the year; Landespreis Oberösterreichische Forscherinnen

2015

Regional award from the state of Upper Austria for Outstanding Research and Collaborative Effort (Winner in the category of Arts and Science)

2005-2006

Award for women with outstanding career track record in science and engineering--WiSE (Women in Science and Engineering)

2003

Outstanding Achievement Award from the University of Southern California, Los Angeles, USA.

 

Invited Speaker

2017

European Society for Evolutionary Biology (ESEB), Groningen, Neatherlands; “Drivers of the evolution of hotspot”.

2017

Austrian Association of Molecular Life Sciences and Biotechnology, Innsbruck, Austria; "Changes in the FGFR3 signaling cause mutations to expand with age in the male germline" (selected talk)

2016

EMBO Meeting, Mannheim, Germany; “Sequence evolution at recombination hotspots”.

2016

Embriologenforum Austria (EFA); "Is sexual reproduction mutagenic“.

2015

The Human Mutation Meeting, Leipzig; "Mutagenesis at recombination hotspots“.

2015

20th Aniversary Meeting of the Science School Universidad de las Americas; "About the origin of mutations in our genome: an analysis at single molecule resolution".

2015

Society of Molecular Biology and Evolution (SMBE) Meeting, Vienna, Austria; "The evolution of short indels at meiotic recombination hotspots". (selected talk)

2014

Embriologenforum Austria (EFA); "The paternal age effect; an analysis of its origins“.

2014

6th OEGMBT annual meeting Life Sciences Meet Entrepreneurship, Vienna, Austria; "Assessment of PRDM9 Zinc Finger binding with DNA of Recombinatin Hotspots". (selected talk)

2010

Austrian Association of Molecular Life Sciences and Biotechnology, Vienna, Austria; "Screening meiotic recombination on microscopic beads 2010". (selected talk)

2008

Marie Curie-- Genome architecture in relation to disease, Madrid, Spain. "High throughput analysis of methylation patterns to track stem cell divisions." (selected talk)

2005

55th Meeting of the American Society of Human Genetics. Platform Session, Salt lake City, USA; "Analysis of fine structure recombination patterns in a human chromosomal region not previously known to harbor a recombination hot spot". (selected talk)

1999

American Society of Mammalogists, Seattle, WA, USA; "Molecular phylogenetics of the Peromyscus boylii species group". (selected talk - best presentation award)

 

Invited Seminars

2018

Austrian Institute of Science (IST),  Lunch seminar series, Host: Nick Barton, “The evolution of polyAs at a recombination hotspot”.

2017

Departmental seminar, Institute of Molecular Medicine, University of Lisbon Medical School: “Age-related mutagenesis of driver genes in the male germline”

2016

Departmental seminar, Penn State University: “Selfish mutations are important drivers of the paternal age effect”.

2015

Departmental seminar Computational and Molecular Biology, University of Southern California: “How meiosis drives the sequence evolution at recombination hotspots”.

2014

Gemeinsamer Seminarabend, Medizinische Gesellschaft OÖ und Johannes Kepler Universität Linz; "Mehr Mutationen dank älteren Männern? Eine Studie von seltenen Mutationen“.

2012

Centro de Biomedicina, Universidad do Algarve, Portugal; "New evidence for positive selection explaining the paternal age-effect observed in achondroplasia"

2011

VetMed University, Vienna; "The enigma of recombination hotspots"

2011

Austrian Institute of Technology, Vienna; "Genetics on microscopic beads-the uses of bead-emulsion amplification"

2010

Austrian Association of Molecular Life Sciences and Biotechnology; "Screening meiotic recombination on microscopic beads".

2009

University of Vienna, Max F. Perutz Laboratories; "What can we learn about meiotic recombination from human sperm?"

2008

Cancer Research Institute, Cambridge, UK; "Can we track the human somatic cell tree using beads?"

2007

Johannes Kepler University, Linz; "Measuring rare events in genomic DNA".

2007

VetMed University, Vienna; "The human somatic cell ancestral tree. Can it be reconstructed using microscopic beads?"

2007

University of Philadelphia, School of Medicine, Department of Genetics; "Spying on sperm to understand recombination".

 

TEAM

Post Docs
Name Position Room Phone Extension E-Mail Note
Dr. Yasmin Striedner              Post Doc 214 7619 yasmin.striedner@jku.at maternity leave
Doctoral Students
Name Position Room Phone Extension E-Mail
Ing. Angelika Heißl MSc Doctoral Student 214 7624 angelika.heissl@jku.at
Ingrid Hartl MSc Doctoral Student 216 7618 ingrid.hartl@jku.at
Renato Salazar MSc             Doctoral Student 214 7623 renato.pereira_salazar@jku.at
Sofia Moura MSc Doctoral Student 216 7618 sofia.moura@jku.at
Theresa Schwarz MSc             Doctoral Student 214 7626 theresa.schwarz@jku.at
Scientific Technicians
Name Position Room Phone Extension E-Mail
Marion Müller BSc                Scientific Technician 219 7621 marion.mueller@jku.at
Master Students
Name Position Room Phone Extension
Gregor Grobner BSc Master Student 216 7618
Nicole Zeppezauer BSc Master Student 216 7613
Bachelor Students
Name Position Room Phone Extension
Georg Weckert Bachelor Student 219 7621
Maja Ivankovic                  Bachelor Student 216 7618
Guests
Name Position
Covadonga Vara MSc                    Doctoral Student from Universitat Autònoma de Barcelona

Alumnae

Former Staff Members
Name Position    
Alexandra Seyer BSc Scientific Technician    
Barbara Arbeithuber MSc Doctoral Student    
Elisabeth Palzenberger BSc Master Student    
Karin Dungl BSc Scientific Technician    
Klaus Radlmaier BSc Scientific Technician    
Marina Giller BSc Master Student    
Maria Kienberger Scientific Technician    
Patrick Ortner BSc Master Student    
Theresa Schwarz BSc Master Student    
Theresa Zacherl BSc Master Student