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Dipl.-Ing. Noura Chelbat

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Persönliche Daten/Ausbildung

  • Enrolled in the PhD Bioinformatics technical science program at the JKU, Linz, Austria
  • Master degree in Molecular Biology and Biochemistry (UMA, Málaga), September 2004
  • B.Sc in Biology (UMA, Málaga), September 2002

Beruflicher Werdegang

Weitere wissenschaftliche Engagements

Forschungsinteressen

  • High-throughput experimental techniques (in general) and their application to understand and solve biomolecular mechanisms underlying biological phenomena
  • Genome and gene expression data analysis. Feature selection on key genes, genetic patterns and markers for cancer-related diseases
  • Microarray platforms curation (including SNPs and CNVs)

Zusammenfassung der Dissertation:

Microarray techniques typically generate many measurements of which only a small subset is informative for the interpretation of the experiment. Through different feature filtering techniques it is possible to select the relevant information from the large pool of noisy data. My work focuses on those informative genes. The goal is to find out the relation(s) between some features of the probes within an informative probe set, namely sequence composition, nucleotide use, physical location in the array and in the chromosomes (targeted position) and annotation.
The elimination of those probes which fail to detect a signal will help with designing microarrays containing only probes that work well or help to find better annotations.This elimination process also filters out those probes that are biologically irrelevant to the experiment.