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Department of Orthopaedics and Traumatology
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Research Focuses.

The working group for Orthopaedics and Traumatology with primary focus on musculoskeletal tissue engineering and regenerative medicine. It provides access to cutting edge technologies, facilities and infrastructure, where we explore innovative methods, cells and materials and utilize 3D bioprinting to regenerate cartilage, bone, tendon and osteochondral tissue. We recycle clinical waste material such as adipose tissue, cartilage, tendon, bone, bone marrow, synovial fluid/membrane and blood to isolate minimally-manipulated regenerative cells, extracellular vesicles (EVs) and tissues. 
To select cell and EV preparations with the best quality profile critical in-depth analyses of the cell identity, property and potency, representative for diverse modes-of-action, are essential. We are addressing immune rejection issues associated with transplant processes and prove our cells for their immunomodulatory and anti-inflammatory activities. 
Together with our collaboration partners, we contribute to the improvement of diverse bioresorbable, functionalised biomaterials and scaffolds through comprehensive analysis of viability, biocompatibility, differentiation, and vascularization in vitro and in vivo. All our focus and efforts are aimed at advancing the field of regenerative medicine and translating our findings into impactful clinical applications.

The Research Group for Musculoskeletal Biomechanics and Implant Research is focused on the biomechanical investigation of the human locomotive apparatus. Mechanical failure experiments and modern simulations, including finite element analysis, are performed to test new solutions for issues in the field of joint injuries, joint replacement, and fracture fixation. Based on a fellowship program, an international cooperation with the AO Research Institute (ARI) in Davos was established. 

The focus of our Clinical Study Center is on the prospective observation and evaluation of all surgically treated medical conditions and implantations, in order to assess and evaluate the benefit for our patients in terms of quality of life, function, and activity. In addition to prospective data collection, retrospective clinical research also serves to scientifically analyse and monitor the outcomes and lifespan of various implants. Studies on hip, knee, and shoulder arthroplasty hold a special significance, as well as investigations in the field of hand, foot, and paediatric orthopaedics. To comply with the guidelines of good scientific practice, all studies are conducted according to GCP criteria and approved guidelines of the ethics committee.