schliessen

A. Univ.-Prof. Dr. Christoph Romanin

Leitung Arbeitsgruppe Ion Channels

Curriculum Vitae

Graduate fellow at the Institute of Organic Chemistry,  Graz University of Technology

Postgraduate fellow at the Inst. of Pharmacology and Toxicology, Univ. of Graz, Austria
 

Postdoctoral fellow at the Institute of Biophysics, University of Linz, Austria
 

University of Miami, Department of Pharmacology, Professor Dr.C.Van Bremen
 

Habilitation for Biophysics at the Institute of Biophysics, University of Linz, Austria
 

Associate Professor at the Institute for Biophysics

NIA, NIH, Bethesda, USA; Professor Dr. N.M. Soldatov

Chairman at the Institute for Biophysics, University of Linz, Austria

Vice-chairman at the Institute for Biophysics, University of Linz, Austria

Alles zeigen

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Publikationen Romanin Lab

Fahrner, M., Stadlbauer, M., Muik, M., Rathner, P., Stathopulos, P., Ikura, M., Muller, N., and Romanin, C. (2018) A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state. Nat Commun 9, 825

Rathner, P., Stadlbauer, M., Romanin, C., Fahrner, M., Derler, I., and Muller, N. (2018) Rapid NMR-scale purification of (15)N,(13)C isotope-labeled recombinant human STIM1 coiled coil fragments. Protein Expr Purif 146, 45-50

Derler, I., Butorac, C., Krizova, A., Stadlbauer, M., Muik, M., Fahrner, M., Frischauf, I., and Romanin, C. (2018) Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus. J Biol Chem 293, 1259-1270

Fahrner, M., Pandey, S. K., Muik, M., Traxler, L., Butorac, C., Stadlbauer, M., Zayats, V., Krizova, A., Plenk, P., Frischauf, I., Schindl, R., Gruber, H. J., Hinterdorfer, P., Ettrich, R., Romanin, C., and Derler, I. (2018) Communication between N terminus and loop2 tunes Orai activation. J Biol Chem 293, 1271-1285

Fahrner, M., Stadlbauer, M., Muik, M., Rathner, P., Stathopulos, P., Ikura, M., Muller, N., and Romanin, C. (2018) A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state. Nat Commun 9, 825

Frischauf, I., Litvinukova, M., Schober, R., Zayats, V., Svobodova, B., Bonhenry, D., Lunz, V., Cappello, S., Tociu, L., Reha, D., Stallinger, A., Hochreiter, A., Pammer, T., Butorac, C., Muik, M., Groschner, K., Bogeski, I., Ettrich, R. H., Romanin, C., and Schindl, R. (2017) Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription. Sci Signal 10

Frischauf, I., Litvinukova, M., Schober, R., Zayats, V., Svobodova, B., Bonhenry, D., Lunz, V., Cappello, S., Tociu, L., Reha, D., Stallinger, A., Hochreiter, A., Pammer, T., Butorac, C., Muik, M., Groschner, K., Bogeski, I., Ettrich, R. H., Romanin, C., and Schindl, R. (2017) Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription. Sci Signal 10

Traxler, L., Rathner, P., Fahrner, M., Stadlbauer, M., Faschinger, F., Charnavets, T., Muller, N., Romanin, C., Hinterdorfer, P., and Gruber, H. J. (2017) Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins. Angew Chem Int Ed Engl 56, 15755-15759

Fahrner, M., Schindl, R., Muik, M., Derler, I., and Romanin, C. (2017) The STIM-Orai Pathway: The Interactions Between STIM and Orai. Adv Exp Med Biol 993, 59-81

Poteser, M., Leitinger, G., Pritz, E., Platzer, D., Frischauf, I., Romanin, C., and Groschner, K. (2016) Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca(2+)-entry. Sci Rep 6, 35656

Frischauf, I., Fahrner, M., Jardin, I., and Romanin, C. (2016) The STIM1: Orai Interaction. Adv Exp Med Biol 898, 25-46

Derler, I., Jardin, I., and Romanin, C. (2016) Molecular mechanisms of STIM/Orai communication. Am J Physiol Cell Physiol 310, C643-662

Derler, I., Jardin, I., Stathopulos, P. B., Muik, M., Fahrner, M., Zayats, V., Pandey, S. K., Poteser, M., Lackner, B., Absolonova, M., Schindl, R., Groschner, K., Ettrich, R., Ikura, M., and Romanin, C. (2016) Cholesterol modulates Orai1 channel function. Sci Signal 9, ra10

Frischauf, I., Zayats, V., Deix, M., Hochreiter, A., Jardin, I., Muik, M., Lackner, B., Svobodova, B., Pammer, T., Litvinukova, M., Sridhar, A. A., Derler, I., Bogeski, I., Romanin, C., Ettrich, R. H., and Schindl, R. (2015) A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription. Sci Signal 8, ra131

Maus, M., Jairaman, A., Stathopulos, P. B., Muik, M., Fahrner, M., Weidinger, C., Benson, M., Fuchs, S., Ehl, S., Romanin, C., Ikura, M., Prakriya, M., and Feske, S. (2015) Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation. Proc Natl Acad Sci U S A 112, 6206-6211

Fahrner, M., Muik, M., Schindl, R., Butorac, C., Stathopulos, P., Zheng, L., Jardin, I., Ikura, M., and Romanin, C. (2014) A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1). J Biol Chem 289, 33231-33244

Raphael, M., Lehen'kyi, V., Vandenberghe, M., Beck, B., Khalimonchyk, S., Vanden Abeele, F., Farsetti, L., Germain, E., Bokhobza, A., Mihalache, A., Gosset, P., Romanin, C., Clezardin, P., Skryma, R., and Prevarskaya, N. (2014) TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. Proc Natl Acad Sci U S A 111, E3870-3879

Zhang, X., Zhang, W., Gonzalez-Cobos, J. C., Jardin, I., Romanin, C., Matrougui, K., and Trebak, M. (2014) Complex role of STIM1 in the activation of store-independent Orai1/3 channels. J Gen Physiol 143, 345-359

Stathopulos, P. B., Schindl, R., Fahrner, M., Zheng, L., Gasmi-Seabrook, G. M., Muik, M., Romanin, C., and Ikura, M. (2013) STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun 4, 2963

Romanin, C. (2013) In this issue of Channels: Special issue on STIM and Orai. Channels (Austin) 7, 329

Fahrner, M., Derler, I., Jardin, I., and Romanin, C. (2013) The STIM1/Orai signaling machinery. Channels (Austin) 7, 330-343

Konig, S., Browne, S., Doleschal, B., Schernthaner, M., Poteser, M., Machler, H., Wittchow, E., Braune, M., Muik, M., Romanin, C., and Groschner, K. (2013) Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle. Am J Physiol Heart Circ Physiol 305, H1646-1657

Derler, I., Plenk, P., Fahrner, M., Muik, M., Jardin, I., Schindl, R., Gruber, H. J., Groschner, K., and Romanin, C. (2013) The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1. J Biol Chem 288, 29025-29034

Zhang, X., Gonzalez-Cobos, J. C., Schindl, R., Muik, M., Ruhle, B., Motiani, R. K., Bisaillon, J. M., Zhang, W., Fahrner, M., Barroso, M., Matrougui, K., Romanin, C., and Trebak, M. (2013) Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. Mol Cell Biol 33, 3715-3723

Lichtenegger, M., Stockner, T., Poteser, M., Schleifer, H., Platzer, D., Romanin, C., and Groschner, K. (2013) A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter. Cell Calcium 54, 175-185

Kaya, L., Meissner, B., Riedl, M. C., Muik, M., Schwarzer, C., Ferraguti, F., Sarg, B., Lindner, H., Schweigreiter, R., Knaus, H. G., Romanin, C., and Bandtlow, C. E. (2013) Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons. Biochim Biophys Acta 1833, 1421-1433

Gonzalez-Cobos, J. C., Zhang, X., Zhang, W., Ruhle, B., Motiani, R. K., Schindl, R., Muik, M., Spinelli, A. M., Bisaillon, J. M., Shinde, A. V., Fahrner, M., Singer, H. A., Matrougui, K., Barroso, M., Romanin, C., and Trebak, M. (2013) Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. Circ Res 112, 1013-1025

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M (2013) STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nature communications 4: 2963

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C. (2011) STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation. The EMBO J 30:1678-89.

Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C (2009) Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel. PNAS 106:19623-8.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S and Romanin C. (2009) Increased hydrophobicity at the N-terminus/membrane interface impairs gating of the SCID-related ORAI1 mutant. J Biol Chem 284:15903-15915.

uik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C (2009) A cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels. J Biol Chem 284:8421-8426.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C (2008) Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem 283:8014-8022.

Singh A, Hamedinger D, Hoda J.-C, Gebhart M, Koschak A, Romanin C, Striessnig J. (2006) C-terminal modulator controls Ca2+-dependent gating of Cav1.4 L-type Ca2+ channels. Nature Neurosci 9:1108-1116.

H. Kahr, R. Schindl, R. Fritsch, B. Heinze, M. Hofbauer, M.A. Hack, M. A. Mörtelmaier, K. Groschner, J.-B. Peng, H. Takanaga, M. A. Hediger and C. Romanin (2004) CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J Physiol 557.1: 121-132.

Wissenschaftliche MitarbeiterInnen

Name Funktion Raum Durchwahl E-Mail
Ing.in Sabine Buchegger Labor   7602 Sabine.Buchegger@jku.at
Dr.in Carmen Butorac Post Doc 120 7606 carmen.butorac@jku.at
Dr.in Isabella Derler Post Doc   7606 isabella.derler@jku.at
Dr. Marc Fahrner Post Doc   7603 marc.fahrner@jku.at
Dr.in Irene Frischauf Post Doc   7603 irene.frischauf@jku.at
Dr. Martin Muik              Post Doc   7605 martin.muik@jku.at
Adéla Křížová MSc Doktorand 120 7606 adela.krizova@jku.at
Ing.in Sonja Lindinger MSc, MSc Doktorand 120 7606 sonja.lindinger@jku.at
Victoria Lunz MSc Doktorand   7603 victoria.lunz@jku.at
Romana Schober MSc Doktorand 217 7611 romana.schober@jku.at
Herwig Grabmayr BSc Masterstudent      
Lena Maltan BSc Masterstudent 217 7611