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GROUP SINGLE MOLECULE GENETICS

Research Interests

Main areas of research: Single molecule analysis of genome dynamics

  • Mutagenesis: mutational processes in the male germline, paternal age effect, mutagenic recombination
     
  • Meiotic recombination: recombination hotspots, regulation of hotspots, hotspot sequence evolution
     
  • Technological developments: ultrasensitive rare variant or mutation detection; bead-emulsionamplification, ultra-sensitive sequencing, single molecule PCR, PCR-based mutation detection