Overview

43 peer-reviewed international publications:

Science Signaling (3), PNAS (1), Embo J (1), Science Advances (1);

Journal of Biological Chemistry^1,2 (13), British J. Pharmacology (1), Cell Calcium³ (3), J Physiol (1)

14 publications as first/contributed equally or last author

16 peer-reviewed publications as co-author

29 original paper

14 reviews (9 reviews as first/last author; 5 reviews as co-author)

Peer-reviewed publications as first/contributed⁺ equally or last author (* corresponding author)

1. Tiffner A., Maltan L., Fahrner M., Sallinger M., Weiß S., Grabmayr H., Höglinger C., Derler I.* Transmembrane domain 3 (TM3) governs Orai1 and Orai3 pore opening in an isoform-specific manner, Frontiers of Cell and Developmental Biology, 2021, 9:635705.
2. Tiffner A, Schober R., Hoeglinger C., Bonhenry D., Pandey S., Lunz V., Sallinger M., Frischauf I, Fahrner M, Lindinger S, Maltan L, Berlansky S., Stadlbauer M., Schindl R., Ettrich R, Romanin C, Derler I. CRAC channel opening is determined by a series of gating checkpoints in the transmembrane and cytosolic regions. J Biol Chem. Dec 2020 :jbc.RA120.015548[1].
3. Fahrner M, Pandey S K, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber H J, Hinterdorfer P, Ettrich R, Romanin C, Derler I Communication between N-terminus and Loop2 tunes Orai activation. J Biol Chem. 2018 Jan 26;293(4):1271-1285.  
4. Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminal. J Biol Chem. 2018 Jan 26;293(4):1259-1270.   
5. Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C. Cholesterol modulates Orai1 channel function., öffnet eine externe URL in einem neuen Fenster Sci Signal. 2016 Jan 26;9(412)
6. Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C. The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1., öffnet eine externe URL in einem neuen Fenster J Biol Chem. 2013 Oct 4;288(40):29025-29034. Epub 2013 Aug 13.
7. Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C. The action of selective CRAC channel blockers is affected by the Orai pore geometry., öffnet eine externe URL in einem neuen Fenster Cell Calcium. 2013 Feb;53(2):139-51. [2]  
8. Bergsmann J, öffnet eine externe URL in einem neuen Fenster, Derler I, öffnet eine externe URL in einem neuen Fenster, Muik M, öffnet eine externe URL in einem neuen Fenster, Frischauf I, öffnet eine externe URL in einem neuen Fenster, Fahrner M, öffnet eine externe URL in einem neuen Fenster, Pollheimer P, öffnet eine externe URL in einem neuen Fenster, Schwarzinger C, öffnet eine externe URL in einem neuen Fenster, Gruber HJ, öffnet eine externe URL in einem neuen Fenster, Groschner K, öffnet eine externe URL in einem neuen Fenster, Romanin C, öffnet eine externe URL in einem neuen Fenster. Molecular determinants within the N-terminus of Orai3 controlling channel activation and gating. J Biol Chem., öffnet eine externe URL in einem neuen Fenster 2011 286: 31565-31575. Impact Factor: 5.6.  
9. Derler I , Fahrner M, Muik M, Lackner B, Schindl R, Groschner K and Romanin C. These three authors contributed equally. A CRAC modulatory domain (CMD) within STIM1 mediates fast Ca²⁺-dependent inactivation of ORAI1 channels. J Biol Chem. 2009 Sep 11;284(37):24933-8.[3] 
10. Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C. Coiled-coil mediated coupling between STIM1 and ORAI channels: Differential activation of ORAI1,2,3 channels by a STIM1 mutant. J Biol Chem. 2009 Aug 7;284(32):21696-706.
11. Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S and Romanin C. Increased hydrophobicity at the N-terminus/membrane interface impairs gating of the SCID-related ORAI1 mutant. J Biol Chem. 2009 Jun 5;284(23):15903-15.
12. Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C. A cytosolic homomerization and a modulatory domain within STIM1 C-terminus determine coupling to ORAI1: Identification of a minimal STIM1 fragments that confers maximal activation of ORAI1 currents. JBC 2009, Mar 27;284(13):8421-6. [4]    
13. Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, öffnet eine externe URL in einem neuen Fenster, Eder P, öffnet eine externe URL in einem neuen Fenster, Schindl R, öffnet eine externe URL in einem neuen Fenster, Hesch C, öffnet eine externe URL in einem neuen Fenster, Polzinger B, öffnet eine externe URL in einem neuen Fenster, Fritsch R, öffnet eine externe URL in einem neuen Fenster, Kahr H, öffnet eine externe URL in einem neuen Fenster, Madl J, öffnet eine externe URL in einem neuen Fenster, Gruber H, öffnet eine externe URL in einem neuen Fenster, Groschner K, öffnet eine externe URL in einem neuen Fenster, Romanin C, öffnet eine externe URL in einem neuen Fenster. Dynamic physical coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem. 2008; 283(12):8014-22; Mentioned as Research Highlight in Nature:  Come together; Vol 451; 503     
14. Derler I, Hofbauer M, Kahr H, Fritsch R, Muik M, Kepplinger K, Hack M, Moritz S, Schindl R and Romanin C. Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca²⁺-dependent inactivation. J. Physiol. 2006; 577(Pt 1):31-44.

Reviews and Commentaries as first/last author

1. Tiffner A, Maltan L, Weiss S, Derler I, The Orai1 pore opening mechanism, Int J Mol Sci, 2020
2. Tiffner A, Derler I, Molecular choreography and structure of Ca2+ release-activated Ca2+ (CRAC) and KCa2+ channels and their relevance in disease with special focus on cancer. Membranes; 2020 Dec 15; 10(12):425.
3. Derler I, Romanin C, Natural photoswitches expose STIM1 activation steps, Cell Calcium, 2020 Sept;90:102240.
4. Butorac C, Krizova A, Derler I, Structure and activation mechanisms of CRAC channels, Advances in Experimental Medicine and Biology, 2020; 1131:547-604.
5. Krizova A, Maltan L, Derler I, Critical parameters maintaining authentic CRAC channel hallmarks, Eur Biophys J. 2019 Mar 21.
6. Derler I, Jardin I, Romanin C. Molecular mechanisms of STIM/Orai communication., öffnet eine externe URL in einem neuen Fenster Am J Physiol Cell Physiol. 2016 Apr 15;310(8).
7. Derler I, Madl J, Schütz G, Romanin C. Structure, regulation and biophysics of I_CRAC, STIM/Orai1. Adv Exp Med Biol. 2012;740:383-410.
8. Derler I, Schindl R, Fritsch R and Romanin C.  Gating and permeation of Orai channels. Front Biosci. 2012 Jan 1;17:1304-22.
9. Derler I, Fritsch R, Schindl R, Romanin C. CRAC inhibitors: identification and potential; Expert Opinion on Drug Discovery, July 2008, Vol. 3, No. 7, Pages 787-800.

Peer-reviewed publications as co-author

1. Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin K D, Sing A K, Cunha M R, Derler I, Gyimesi G, Reymond J L, Hediger M A, Romanin C, Sobolevsky A I, Inactivation-mimicking block of the epithelial calcium channel TRPV6; Sci Adv. 2020 Nov 27;6(48):eabe1508.
2. Waldherr L, Tiffner A, Misha D, Sallinger M, Schober R, Frischauf I, Schmidt T, Handl V, Sagmeister P, Köckinger M, Derler I, Ücal M, Bonhenry D, Patz S, Schindl R, Blockage of store-operated Ca2+ influx by synta66 is mediated by direct inhibition of the Ca2+ selective Orai1 pore. Cancers (Basel) 2020 Oct 6; 12(10):2876.
3. Sallinger M, Tiffner A, Schmidt T, Bonhenry D, Waldherr L, Frischauf I, Lunz V, Derler I, Schober R, Schindl R. Luminal STIM1 mutants that cause tubualaraggregate myopathy promote autophagie processes; Int J Mol Sci 2020 jun 21; 21(12):4410
4. Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos P B, Romanin C, Ettrich R H, Schindl R, Sequential activation of STIM1 links Ca2+ with luminal domain unfolding, Sci Signal. 2019 Nov 19; 12(608):eaax3194.
5. Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, Salido GM, Smani T, Rosado JA, Redondo PC. STIM1 phosphorylation at Y³¹⁶ modulates its interaction with SARAF and the activation of SOCE and I _CRAC., öffnet eine externe URL in einem neuen Fenster J Cell Sci. 2019 May 15;132(10).
6. Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A, Lindinger S, Schober R, Frischauf I, Bhardwaj R, Hediger M A, Groschner K, Romanin C. A novel STIM1-Orai1 gating interface essential for CRAC channel activation. Cell Calcium. 2019; Volume 79, öffnet eine externe URL in einem neuen Fenster, May 2019, Pages 57-67
7. Rathner P, Stadlbauer M, Romanin C, Fahrner M, Derler I, Müller N. Rapid NMR-scale purification of ¹⁵N,¹³C isotope-labeled recombinant human STIM1 coiled coil fragments., öffnet eine externe URL in einem neuen Fenster Protein Expr Purif. 2018 Feb 1;146:45-50.  
8. Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R. A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca²⁺ permeation and SOCE-induced gene transcription. Sci Signal. 2015 Dec 22;8(408):ra131.
9. Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways., öffnet eine externe URL in einem neuen Fenster Br J Pharmacol. 2012 Dec;167(8):1712-22.
10. Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C. STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation., öffnet eine externe URL in einem neuen Fenster EMBO J. 2011 May 4;30(9):1678-89. Epub 2011 Mar 22.
11. Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C. Cooperativeness of Orai cytosolic domains tunes subtype-specific gating., öffnet eine externe URL in einem neuen Fenster J Biol Chem. 2011 Mar 11;286(10):8577-84.
12. Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ. Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells., öffnet eine externe URL in einem neuen Fenster J Biol Chem. 2010 Dec 24;285(52):41135-42.
13. Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C. Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel., öffnet eine externe URL in einem neuen Fenster Proc Natl Acad Sci U S A. 2009 Nov 3,
14. Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C. 2-Aminoethoxydiphenyl borate alters selectivity of ORAI3 channels by increasing their pore size; J Biol Chem. 2008 Jul 18;283(29):20261-7.
15. Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K and Romanin C. The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo and heteromeric TRPC4/TRPC5 channels. Cell Calcium. 2008; 43(3):260-9;
16. Poteser M, Graziani A, Rosker C, Eder P, Derler I, Zhu MX, Romanin C and Groschner K. *These authors contributed equally. TRPC3 and TRPC4 associate to form a redox-sensitive cation channel - Evidence for expression of native TRPC3/ TRPC4 heteromeric channels in endothelial cells. J Biol Chem., 2006, 281(19):13588-95.

Reviews as co-author

1. Fahrner M, Schindl R, Muik M, Derler I, Romanin C. The STIM-Orai Pathway: The Interactions Between STIM and Orai. Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. 
2. Fahrner M, Derler I, Jardin I, Romanin C. The STIM1/Orai signaling machinery., öffnet eine externe URL in einem neuen Fenster Channels (Austin). 2013 Oct 9;7(5).
3. Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C. Recent progress on STIM1 domains controlling Orai activation., öffnet eine externe URL in einem neuen Fenster Cell Calcium. 2009 Oct;46(4):227-32.
4. Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C. Mechanistic view on domains mediating STIM1-Orai coupling. Immunol Rev. 2009 Sep;231(1):99-112.
5. Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C., öffnet eine externe URL in einem neuen Fenster The STIM/Orai coupling machinery. Channels (Austin). 2008 Jul-Aug; 2(4):261-8.

[1] Selected as editor’s pick.

[2] this paper is one of the 5 most highly cited papers published in Cell Calcium

[3] selected as the paper of the week

[4] mentioned as Research Highlight in Nature:  Come together